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Screw the Woo Woo – Don’t Use Ivermectin Unless You Have Worms (And Please Don’t Drink Your Own Pee) to Treat COVID

/ D.B. Sieders / Leave a comment

I can’t believe I have to write this post. I’m shaking my head and weeping for the future of humanity as I write it. Are people really stupid enough to believe that ivermectin – a drug we use in our laboratory mice to treat pinworms (butt worms) – can cure Covid?

Yes (sadly). Yes, they are.

This is what came up when I searched for Ivermectin. I have to adjust the search…
These are related searches…people, just, just don’t…

Ivermectin is used to treat butt worms in animals. It can also be used to treat roundworms in people. It works by paralyzing worms, specifically by binding to proteins on motor neurons (nerves that tell muscles to move) and disrupting their activity. It also mucks around with the ability of nematode worms to reproduce.

Photo Credit Deposit Photos

Fun fact: the naturally occurring analogs of ivermectin, avermectins, were discovered in bacteria from soil samples collected by Dr. Satoshi Ōmura from woods near a golf course in Kawana, on the south east coast of Honshu, Japan. The name “avermectin” reflects the activity of these compounds, making treated organisms “worm free.” Dr. Ōmura and Dr. William Campbell shared the 2015 Nobel Prize in Physiology or Medicine for this discovery. You can read more about that here. Ivermectin in pill form can be used in humans to treat parasitic worms, and topical (on the skin) formulations are also used to treat head lice and rosacea.

It does actually have other, non-butt worm related activities that include treatment of severe muscle spasticity in patients with spinal cord injuries and shows activity against leukemia in laboratory animal models. It may also target molecular pathways relevant to treatment of other cancers, including lung and colon cancer and glioma based on laboratory animal studies, and could block inflammatory T-cell activity in atopic dermatitis, relieving irritation. A recent review covers the research on these applications.

Okay, given these other potential applications, I guess I can kinda sorta see why some folks without a science background might be buying into the idea of using Ivermectin to treat Covid, but(t) still…

This apparently became trendy because of ongoing clinical trials designed to test the efficacy of Ivermectin for Covid-19 treatment and prevention, alone and in combination with other drugs.

Why? Because laboratory studies (in petri dishes in a lab, NOT in people) have shown that Ivermectin can inhibit viral replication, which means it can stop the virus from making copies of itself, which is how it spreads. In vitro. In vitro means “performed or taking place in a test tube, culture dish, or elsewhere outside a living organism.” Plenty of other previous studies showed that ivermectin blocks replication or interferes with the production and spread of other viruses, including HIV, Dengue virus, West Nile virus, and a few others. In vitro. You can review some of these studies here. In spite of these in vitro studies, there is no evidence that ivermectin has any anti-viral effect on the SARS-CoV-2 virus that causes Covid-19. For a link to clinical trial data, click here.

And misuse of ivermectin can be dangerous. According to the FDA, “Even the levels of ivermectin for approved human uses can interact with other medications, like blood-thinners. You can also overdose on ivermectin, which can cause nausea, vomiting, diarrhea, hypotension (low blood pressure), allergic reactions (itching and hives), dizziness, ataxia (problems with balance), seizures, coma and even death.”

The best way to limit the spread of SARS-CoV-2 is to get the vaccine. Period.

And Now for the PSA I never thought I’d have to make…

About the whole so-called “urine therapy” thing – something I never in a million years imagined I would blog about. It isn’t a thing. Apparently, some anti-vaxx conspiracy theory wingnut named Christopher Key has been encouraging his followers to drink their own urine to ward off the SARS-CoV-2 virus instead of getting vaccinated.

What. The. Fuck.!?!?

Spoiler Alert – urine does fuck all for COVID-19.

Kids, please don’t take advice from people with mugshots…

For the sake of being thorough and due diligence, I performed a PubMed search for “urine therapy covid” on January 16. The search produced 188 results, most dealing with the effects COVID-19 on kidney function, studies related to the potential spread of the virus through urine (risk reported to be negligible), urine-based COVID-19 testing and analysis of cytokines and other diagnostic markers, and testing for SARS-CoV-2 in waste water.

The funniest result was a paper with the title, “Influence of perceived threat of Covid-19 and HEXACO personality traits on toilet paper stockpiling” published in PLoS One.

This one was more sad than funny, but apparently some folks in India are using cow dung to treat COVID-19. People…rubbing animal shit and urine all over your body isn’t effective at treating ANYTHING and is likely to expose you to a whole lot of nasty zoonotic (spread by animals) diseases. Plus you’ll stink. Just…don’t.

You know what I didn’t find in my literature search? I didn’t find a single peer-reviewed study endorsing the use of drinking your own piss as a treatment for COVID-19. Zero, zip, zilch, nada – no evidence to back up this ridiculous claim.

Not that the crazies need silly things like evidence. This actually fits quite nicely with the all-natural woo woo trends. Can you picture it? All natural, locally sourced, sustainably harvested on tap pee pee for your health needs! You’ve heard of eating placenta (don’t do that, either), but why stop there? Drink your pee! When it’s fresh, it looks like a beer.

Sure doesn’t taste like beer. Stick to drinking nice, cold brewskies, and get your vaccine. Please.

Screw the Woo Woo: Apple Cider Vinegar

/ D.B. Sieders / 2 Comments

This is an oldie that keeps cropping up in the sphere of (completely unvetted) wellness tips – apple cider vinegar. I’m a bit puzzled by the claims that this is a “natural remedy.” Apples are natural. Cider is processed, as is vinegar, through a fermentation process involving bacteria and yeast that occurs on an industrial scale. It’s not magic. It’s chemistry.

Anyway, a Google search revealed top hits chock a block FULL of Woo Woo claims that are fantastical in nature and, you guessed it, not scientifically vetted. The “apple cider vinegar process” is only at the top because I searched for it first, I suspect. But the rest – “apple cider vinegar gummies” (gross!), “apple cider vinegar benefits” (makes foods taste yummo, but that’s it), “apple cider vinegar pills” (WTF?), “apple cider vinegar weight loss” (maybe if all you eat are salads with apple cider vinaigrette dressing – but that’s a sad way to live), and “apple cider vinegar diet” (that doesn’t even make sense) – it’s all a bunch of doo doo!

“My grandfather’s work was doo doo!” Young Frankenstein. Photo source.

But, since I’m a debunker of woo woo scams, I’m doing the research. A PubMed (database of peer-reviewed published biomedical research) search using “apple cider vinegar” yielded 94 results. Aside from a few articles on the antimicrobial and anti-fungal properties of ACV (not surprising, considering that ACV contains 5-6% acetic acid) and studies in rodent models (cardiovascular health, obesity, and something about boosting immunity in carp and – those were weird) that may or may not translate to humans, most of the articles covered the dangers of using ACV as a “natural remedy.”

Photo credit here.

For example, tooth erosion and esophageal injury was documented in at least two studies [Case Reports Ned Tijdschr Tandheelkd. 2012 Dec;119(12):589-91. doi: 10.5177/ntvt.2012.12.12192 “Unhealthy weight loss. Erosion by apple cider vinegar”; J Am Diet Assoc. 2005 Jul;105(7):1141-4. doi: 10.1016/j.jada.2005.04.003. “Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products.”]. Seriously, do NOT use this to treat heartburn or GERD. It’s a fucking ACID and adding ACID to a condition caused by escape of stomach ACID is completely ridiculous. Don’t drink it. Cook with it, but don’t drink it.

Not only does ACV have no benefit for atopic dermatitis [(skin irritation) Pediatr Dermatol 2019 Sep;36(5):634-639. doi: 10.1111/pde.13888. Epub 2019 Jul 22. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity], topical skin treatments with ACV can cause chemical burns [J Am Acad Dermatol. 2012 Oct;67(4):e143-4. doi: 10.1016/j.jaad.2011.11.934. “Chemical burn from topical apple cider vinegar.”]! Don’t put it on your skin. Please.

One study reported a lack of antiglycemic (lowering of blood sugar) by vinegar, including ACV, in humans [Nutr Res. 2009 Dec;29(12):846-9. doi: 10.1016/j.nutres.2009.10.021. “Vinegar lacks antiglycemic action on enteral carbohydrate absorption in human subjects.”]. So no, it won’t help people with diabetes.

Apple cider vinegar and a paper funnel inserted into a cup are used as an at home fruit fly trap. Photo credit here.

Fun rando fact – apparently ACV attracts several species of fruit flies, so if you want to collect some wild ones as pest control or for DIY experiments at home, try it! I’m not citing these. Look it up yourself. There are a surprising number of studies documenting this.

Bottom line – there are no validated health benefits in humans for this “natural remedy,” but there are plenty of bad things that can happen if you drink a lot of cider vinegar, put it on your skin, or take pills (and presumably gummies).

And ACV does NOT cure or treat cancer. Only two references came up in a PubMed search for “apple cider vinegar cancer,” and neither reported any benefits for treatment of warts or moles, let alone skin cancer.

BUT…ACV can make tasty salad dressings and delicious sauces. One of my favorites for fall is apple glazed baked chicken. Here’s the recipe:

Ingredients:

1 whole broiler chicken, apple jelly, apple cider vinegar, apple pie spice, apples (tart or sweet)

Recipe

Preheat oven to 325 degrees. Season the chicken with olive oil, salt, and pepper. Bake chicken for 1 1/2-2 hours. While chicken is baking, slice apples and prepare glaze. To prepare glaze, heat 1/2 jar of apple jelly with an equal volume of apple cider vinegar and 1-2 teaspoons of apple pie spice. Boil until volume is reduced by 1/2. Remove chicken from oven, drain chicken stock (can be used to prepare some DELICIOUS rice), cover with glaze, and place apple slices around chicken in the baking dish. Cook another 1/2 hour or until chicken is done. Serve with rice or potatoes, green beans, and enjoy!

Screw The Woo Woo: Essential Oils Won’t Cure Your Cancer

/ D.B. Sieders / Leave a comment

Essential oils. They’re EVERYWHERE! Articles and posts touting their alleged benefits are all over social media, some news media, and the Internet. A Google search I performed today yielded 1.7 billion results. 1.7 BILLION! Yup, there’s a LOT of buzz about the wonders and medicinal benefits of essential oils.

And almost all of it 100% certified Grade A Bullshit.

This post is dedicated to debunking one of my least favorite bullshit woo woo scams (second only to homeopathy). And I will do so with the power of science and snark, because that’s just who I am as a person.

So what are essential oils? They are oils purified from plants and carry the aroma of the source from which they are extracted. Their name comes from the fact that they are thought to contain the essence of their source, and they smell pretty good thanks to terpenoids, aromatic organic compounds produced by plants that often function as chemical protection against herbivores, insects, and microbes. They also serve as attractants for pollinators, seed dispersers, and in mediating plant–plant and plant–microbe communication. Humans enjoy them because they smell and in some cases taste really good. Sadly, allergies prevent me from enjoying the florals, but I enjoy herbals and fruit oils in a wide array of products – cosmetics, soaps, perfumes, lotions, bath products, and many food items. They’re just nice.

Fresh herbs and oils, wooden table background – we smell good and taste nice!

But do they have any medicinal value? What about medicinal value when it comes to cancer? Part of the issue with answering this question involves the (lack of) regulation when it comes to production and testing. The concentration of active chemicals in extracts can vary widely from plant to plant, which parts are processed (different concentrations in leaves, flowers, stems, and roots), which season the plants are harvested, which strains are sourced, etc. Without consistent batches subjected to quality control to assure consistent concentrations of active chemical components (like terpenoids), and without rigorous, scientific studies, we can only rely on anecdotal evidence and (often misleading) claims from suppliers. Some efforts are being made by the WHO for quality and safety evaluation of herbal products, including chemical fingerprint analysis*. Much like vitamins and supplements, which are not subject to the same rigorous FDA standards for safety and efficacy (how well it works) as drugs, essential oils fall under the category of “safe for their intended use,” which does not involve use as medical treatments. They’re considered safe until proven otherwise, a MUCH lower standard than FDA approved drugs.

More importantly, they are (by fairly low standards) rated for safety, but not for EFFICACY. That would require clinical trials and rigorous testing.

Should we be researching them? Sure! Some pre-clinical studies involving cultured cells (cells grow in a petri dish under laboratory conditions) and animal (primarily mouse) models have been published. A systematic review of the literature from 2014 to 2019 identified 79 studies that fit inclusion criteria – including studies investigating essential oils with anti-microbial and immunomodulatory (affects the host immune response) properties, nutrition studies, studies with controls and proper statistical analyses. Of those studies, many documented the anti-microbial (bacteria fighting) and anti-fungal (fungus fighting) properties, antioxidant properties that may help slow food spoilage, and anti-inflammatory properties in laboratory and agriculture models. And, in some preclinical studies, high doses of essential oils can kill cancer cells in culture in a laboratory setting. Does that mean they’ll do the same thing in humans? Not necessarily. See my post on turmeric.

Just for perspective, it’s pretty easy to kill cancer cells in culture in a laboratory setting. I once killed a dish by accidentally leaving the cells in phosphate buffered saline instead of growth media. Yes, salt water can kill cancer cells in culture. So can many drugs, but the majority of compounds with anti-cancer activity in cultured cancer cells and mouse models are not effective in human clinical trials. So, the jury is out on whether or not the active ingredients essential oils can help treat cancer. And inhaling the pleasing aromas produced by essential oils may effect mood, but it doesn’t do anything to thwart cancer growth, survival, or invasion.

These observations definitely warrant more laboratory investigation, but as of this post, there is no evidence that essential oils fights cancer when inhaled or ingested or delivered in any other way into the human body. Advertisements by scammers like the ones listed below are lies:

These are some of the top hits under a Google search for “treating cancer with essential oils.” As is my standard policy, I will not share links for woo woo. The misinformation and outright lies are not only infuriating, they can prove deadly for patients who skip standard therapies in favor of alternative “therapies.” The stats are heartbreaking. In a Yale School of Medicine study (link to original publication here*), “patients who used alternative medicine in place of standard evidence-based medicine had a death rate 2.5 times higher than patients who received standard evidenced-based therapies.”

Women with non-metastatic breast cancer who opted for alternative “medicine” were ~ 6 times more likely to die within 5 1/2 years compared to women who received standard of care therapy. This is a small study – 281 patients – and captures data from patients who disclosed their decision to follow alternatives versus standard of care. It doesn’t include patients who do not disclose or discuss this with their health care providers, so the numbers could actually be higher.

For more information on aromatherapy – separating fact from fiction – click here. Check out this article, too. Bottom line: much like cannabis, essential oils may offer relief from the side effects of standard of care treatments, but they cannot cure cancer nor should they be used as a substitute for standard of care. Complimentary alternative medicine is fine, as it compliments proven therapies, but not on their own.

*Access to this article is limited by a paywall. If you want to read it for yourself, hit me up and I’ll send the PDF.

Screw the Woo Woo: WTF is up with Gwyneth Paltrow and Vaginas/Butt Stuff??

/ D.B. Sieders / 1 Comment

Like many actual scientists and rational human beings, I have issues with Gwyneth Paltrow’s activities as a “wellness guru” by way of her company, GOOP. Don’t get me wrong, she’s an incredible actress and supports some great philanthropic work, including the work of The American Cancer Society and The Breast Cancer Research Foundation. And I don’t have a big problem with her capitalizing on her fame and looks in the beauty industry. We all like to look and feel pretty.

But GOOP as a resource for health and wellness is another matter. From coffee enemas for “detox” (note – all you need for detox are a liver and functional kidneys), vaginal steaming (that’s a recipe for a rip-roaring yeast infection and severe burns), and jade eggs to stick up your vagina (not healthy – and don’t just take my word for it; Dr. Jen Gunter, OB/GYN and author of The Vagina Bible confirms what common sense would tell most women: nothing good can come from sticking rocks up your hoohah), this whole “wellness” thing is actually pretty freakin’ unhealthy. So much so, in fact, that a lawsuit cost the biz $145K (for baseless claims about the benefits of vagina eggs – really just a drop in the bucket for them) and now they include disclaimers about their whackadoodle health claims.

And…now she’s selling a candle that allegedly smells like her vagina. You can’t make this shit up. The candle is called “This Smells Like My Vagina.” It’s right there in the name. Now, I’m not going to unpack all of the patriarchal bullshit that goes along with how women’s bodies should look and smell – your vagina smells fine. Trust me. It smells like it’s supposed to. No one is marketing products to freshen up sweaty ballsacks, which tells you pretty much everything you need to know about sexist double standards when it comes to eau de genitals.

But aside from all of that, what does Gwyneth’s snatch-scented candle (allegedly) do? And, I have to ask, did she actually stick the candles into her snatch to infuse them with her feminine “energy” and alluring musk? Apparently, this candle actually smells like “a blend of geranium, citrusy bergamot, and cedar absolutes juxtaposed with Damask rose and ambrette seed [note – um, that’s not what vagina’s smell like] that puts us in mind of fantasy, seduction, and a sophisticated warmth.”

Well, at least she didn’t claim it cures cancer, so bonus.

This is the same woman who falsely claimed that underwire bras could cause breast cancer – they can’t and don’t. That shit really pisses me off. She’s not a trained healthcare provider, a scientist working in a laboratory (the GOOP “lab” show that’s coming to Netflix is NOT a lab and I’m probably going to rage post and Tweet about all of the false claims that will no doubt come out of that train wreck), and she has no expertise in this arena. So, my advice to Gwyneth Paltrow is this: stay in your fucking lane. You’re an actress, not a health expert.

Seriously, there’s nothing inherently wrong with a bit of…whimsy when it comes to lifestyle choices. If it feels good and it doesn’t hurt you, then, hey, you do you. The problem is that much of what overpriced celebrity brands like GOOP peddle actually CAN hurt you (remember that whole vaginal burn thing a few paragraphs back?). Worse, in this age of anti-intellectualism, where a large segment of the world population does not value or respect scientists and healthcare provider expertise, celebrities have become a go-to for “the answers” to all of your health woes. That’s a problem.

So what do we do? For starters, use common sense. If something sounds weird (even if it’s allegedly been practiced for centuries by ancient wise women in some place the seller is culturally appropriating for financial gain), it’s probably a scam. If your healthcare providers and people with actual degrees and expertise (e.g. SciBabe, Jen Gunter, Sana Goldberg – Dr. Oz totally does NOT count) advise against it, it’s probably a scam. If it’s a seemingly ordinary item (vagina scented candle) that costs a ridiculous amount of money ($75 – what the ACTUAL fuck), it’s probably a scam. Be smart, stay safe, and don’t be fooled!

Click here for some more hilariously/sad/ridiculous vagina trends from Ms. Paltrow . For SciBabe’s entertaining and informative take on Gwyneth Paltrow and GOOP, click here.