I love you with all my boobs. I would say my heart, but my boobs are bigger
I’ve spent twenty years working as a biomedical breast cancer researcher. Then, I was diagnosed with breast cancer. I thought I knew breast cancer before it whacked me upside my left boob and left me bleeding on the curb of uncertainty. I thought I knew cancer. I had a lot to learn. The purpose of this blog is to share my personal adventure with breast cancer, from the laboratory bench to my own bedside, and to provide accessible information about breast cancer biology for non-scientists. I say adventure, because I’d rather think of it as action movie with some really cool side quests instead of another tragedy-to-triumph saga. I’m not big on sagas. I am big on kickass intellectual badassery, pathological nerdiness, and talking about my sweet, sweet rack.
I’ll be posting about breast structure and function, how breast cancers arise from normal breast tissues. Notice I wrote “cancers” instead of “cancer.” Breast cancers are a actually a collection of diseases, and all breast cancers are different. To date, there are at least 5 subtypes, and subtypes within those subtypes.
It’s complicated, which is one reason why we haven’t cured these diseases. Another reason is how tricky and adaptable cancers are by their very nature. We’ll get into all of that in a few posts. In the meantime, let me get into the other purpose of this blog: fighting pseudoscience and scams with peer-reviewed, vetted science.
We live in an age of fake news and pseudoscience, made worse by the pervasive anti-intellectual and anti-science political culture gripping the United States and much of the world. The Internet and social media are plagued by scammers selling “alternative medicine” and woo woo “cures” for cancer. Through TALKING TATAS, I offer accurate, evidence-based science that is accessible to laypersons, including the more than three hundred thousand individuals diagnosed with breast cancer every year*, their caregivers, and their loved ones. Submit questions, ask for follow-up on any and all posts, be a part of the discussion. Knowledge is power, and it can save lives!
One of the things I love about my work in advocacy is discovering amazing people who are doing the work and making a difference! Valeda Keys is one such remarkable person. She’s a Global Ambassador for Breast Cancer Awareness, using her platform and the Non-Profit organization she founded, Valeda’s Hope, to assist women in their journey from diagnosis to remission. She has one hell of a compelling story that includes a family history of breast cancer, a personal battle with breast cancer that included seven surgeries, and finding strength and empowerment in helping others.
When I learned about her work on LinkedIn, I was blown away.
Valeda, who is an Author, Speaker, LPN, Non-Profit Founder, Breast Health Navigator, and all around incredible human being, helped her mother through a breast cancer diagnosis, treatment, and later recurrence. A dream told her that she would one day endure her own battle with breast cancer, which unfortunately came true in 2010. Luckily, because of her family history, Valeda started receiving mammography screening at the age of 27 and kept up with her screenings, which allowed her healthcare team to detect her first breast cancer at an early stage. After a lumpectomy, she received the results of her genetic testing, which revealed that she carries a variant of theBRCA-2(BReast CAncer gene 2) gene associated with an increased risk of breast and ovarian cancer.
Quick Science Break
Everyone has two BRCA1 and two BRCA2 genes, but sometimes a variant of one of these genes that doesn’t work gets passed down from one of your parents. If something happens to the other copy of the BRCA gene in a cell (for example, a cell from your breast or ovary), it can increase your risk for cancer. Why? BRCA genes encode information to make proteins that help fix damage to DNA. DNA molecules encode and store all the information a cell needs to make proteins, which allows a cell to live and perform its function. When DNA is damaged, it messes with the code, and if the damage isn’t repaired, cells make defective proteins that don’t function well or in the case of cancer-causing oncogenes, function too well. Defects in some genes make cells grow uncontrollably, and sometimes those cells turn into cancer cells. Variants of BRCA genes that don’t function to fix DNA damage makes it more likely for oncogenes to get activated and make cells grow uncontrollably, leading to cancer. In the graphic above, you can see a DNA repair deficient breast cell in which the BRCA genes encode DNA repair proteins that don’t work. Because the defective BRCA gene produces a defective protein, the cell can’t repair DNA damage and gets a lot more mutations in a lot of different genes. Some of these mutations create defective proteins that let the cell grow uncontrollably, even without estrogen (E2) or other cues from the body that tell cells when to grow. See my Cancer 101 blog post and my other blog poston how cells become cancerous for a refresher on the cell biology of breast cancer, DNA damage and how it leads to cancer, and oncogenes.
End Science Break
Now, back to Valeda’s story. Since she carries a variant of BRCA-2 that doesn’t work, she was still at risk for getting another breast cancer or ovarian cancer after her first breast cancer diagnosis. She decided to keep her breasts and get screened more often, a valid choice. (Note: there are no right or wrong choices when it comes to keeping your breasts or having a double mastectomy. There are only informed choices you make with your healthcare team that are right for you.). She also endured radiation therapy that led to some serious complications, and was treated with tamoxifen, a drug that blocks estrogen function. In spite of this, she was diagnosed with a new breast cancer in 2011 and opted for a double mastectomy and autologous reconstruction (i.e. reconstruction using her own tissue from her abdomen to build new breasts), which unfortunately came with some complications, and later had a hysterectomy.
Through it all, she remained focused and determined not to let breast cancer get in the way of living a full life and achieving her goals. Her faith helped her through, and it gave her a mission to educate, empower, and help other women through their own breast cancer journeys. Among the many amazing things she does through Valeda’s Hope, Valeda sponsors a ton of mobile mammography events and encourages women to keep up with life-saving screenings. She shares her knowledge and experience through speaking engagements and educational events like Valeda’s Hope Pink & Pearls Luncheons. Valeda also hosts events that provide emotional and physical support as well as information about genetic testing for breast cancer risk genes, and so much more.
I’ve said it before, and I’ll say it again: the breast cancer survivor community is so supportive! Survivors support other survivors, patients, and caregivers. As a survivor, Valeda is using her voice and actions to help other women survive and thrive, and that deserves a spotlight, kudos, and celebration!
It’s funny. I’ve been meaning to write more blog posts, but I’ve been so busy with work, family, writing, and…COVID. My whole family got the ‘Rona and it sucked. Fortunately, we’d been vaccinated, and my husband and I had been boosted. It didn’t result in hospitalization or death. We were lucky. My birth mother, Mary Etta Caldwell, was not. We lost her to Covid and I’m still reeling. PSA – the pandemic isn’t over. It’s still killing people. It’s still debilitating people with long haul Covid. Get vaxxed/boosted and stay safe out there.
Now, onto the main event. This one’s a fucking RIOT!!!
I don’t know if this was from a bot, but I’d like to think it’s from a man. I picture a middle-aged white man who is possibly unemployed and likes to slide into women’s DMs and make sexist comments, spew pseudoscience woo woo, and is a fan of Trumplican propaganda on Facebook and Twitter. We’ll call him Arthur – because that’s what his profile says!
Arthur is very concerned about me and my health. So concerned, in fact, that he reached out in a very sincere and grammatically sound Facebook Message to save me. Now, he hasn’t read my book—though he promises he will and I totally believe him—but he has vital information that he must share with me. Aren’t I lucky?
Arthur has the secret to cancer. Are y’all ready? It’s a dry rot fungus addicted to sugar, and all you need to kill it is hot water.
But if I REALLY want to keep the fungus at bay, I need to “maintain a LOW GLYCEMIC diett” and since “your carryinga little extra weight,” I must still be eating a high glycemic carb “amoint.”
Now, I’ve received flak before for pointing out bad grammar and spelling in personal attacks, but come on! This fucker reached out to me, a breast cancer survivor and researcher, with unsolicited advice and, quite frankly, the STUPIDEST explanation for cancer I’ve ever heard—and I’ve heard some real doozies.
But, beyond the poor grammar, spelling, and general stupidity, there is so much more fodder here for me to unpack. Firstly, mansplaining. It’s a thing. Ask any woman in your sphere and she’ll tell you. She won’t even have to think about it, and will probably come up with five personal experiences in less than a minute. I am an expert in the field of breast cancer. Not sort of, kind of, I guess I know a little—I’m a bona fide expert in the field with a Ph.D. and more than twenty years of experience studying the disease. I also have personally experienced breast cancer IN MY BODY. I know what I’m talking about, and the information I share is carefully researched and derived from peer-reviewed scientific publications.
I doN’t nEEd arTHur to eXplaIN caNcer to mE.
And yet, like so many mediocre white male living examples of Dunning-Kruger, he just couldn’t help himself! Yes, I’m singling out white men. No, I don’t think it’s out of line. If you’re a white man and you’re offended, then you’re an Arthur and you need to rethink your life choices and behavior. If you’re not offended, you’re an ally and you should call out the Arthurs in your life because they’ll listen to you as a fellow white man. You can do it. It’s easy and fun.
Next, the fungus thing. I don’t think Arthur is giving white rot fungus a fair shake. Apparently, it is quite a useful organism that plays a vital role in the global carbon cycle by breaking down lignin, an organic polymer component of plant cell walls, especially in wood and bark, that lends rigidity and do not rot easily. If we didn’t have dry rot fungi, we’d have a whole lot of dead trees mucking up the planet.
But Dr. Dana, does it cause cancer??
Of course not!* In fact, an early pre-clinical study performed in colon cancer cell lines reported that extracts from a species of dry rot fungus, Cerrena unicolor, caused cancer cells to die in culture. That’s right, my friends. I think white rot fungi should sue Arthur for slander. Arthur is spreading malicious propaganda against this very useful organism that does more good on planet earth than Arthur could ever hope to achieve. Clearly, Arthur is jealous.
Now, as for sugar and cancer, it’s complicated. Biology is complicated. Anyone who says anything different is trying to sells you bullshit supplements. I wonder if Arthur sells supplements… Anyway, metabolism consists of a complex series of interconnected biochemical reactions that convert food energy into cellular energy required to fuel cellular processes, generate building blocks necessary to create/sustain/repair biomass, and eliminate cellular waste. Metabolism gets fucked up in very interesting ways in cancer cells and in the cells that surround it (microenvironment). Obesity is a metabolic health issue and a risk factor for breast cancer.
However, as noted by the American Cancer Society, “But the connection between weight and breast cancer risk is complicated. Studies suggest the risk appears to be increased for women who gained weight as an adult but may not be increased among those who have been overweight since childhood. Also, having extra fat in the waist area may raise risk more than having extra fat in the hips and thighs.” There are many, many dedicated, highly trained, competent scientists and physicians studying the complexities of metabolism, and there’s plenty they still don’t know.
I guarantee they know WAAAAAAAAAAAAY more about the subject than Arthur, who has no medical degree, no credentials, and no peer-reviewed studies to back up his assertions. The only thing he has is the audacity. As for the not-so-subtle dig on my weight, I can’t say it better than Lizzo. I’m a big bitch. I don’t have a tour bus, but I’ve got a degree, a platform, and I do a lot of good in the world. What do you do that’s worth anyone’s while, Arthur?
*If you want to hate on fungi linked to cancer, you should really go for Aspergillus flavus and Aspergillus parasiticus. They produce aflatoxins, and exposure to those increases liver cancer risk.
In summary, in a world full of Arthurs, be a Lizzo.
I was going to end it here, but Arthur slid back into my DMs to leave these little nuggets of wisdom:
No, I’m not clicking on any of those links, because I don’t want a computer virus. Somehow, I don’t think this is the only virus Arthur is carrying. I hope you’ve found this post informative and entertaining, because I had a HOOT writing it! Thank you, Arthur.
Cancer is a great and terrible equalizer. It doesn’t care if you’re a Democrat, Republican, Independent, or if you support other political philosophies or are apolitical. Anyone can be diagnosed with cancer. For breast cancer, access to routine screening and diagnostic imaging is critical for early detection, accurate diagnosis, and receiving treatments in a timely fashion.
It can literally mean the difference between life and death.
When breast cancer metastasizes, or spreads to other parts of the body, time is precious, and people living with metastatic breast cancer need all the financial and medical support they can get.
How can you help? There are two pieces of legislation in need of support and a federal program in desperate need of reauthorization:
The first piece of legislation, the Access to Breast Cancer Diagnosis (ABCD) Act, will reduce out-of-pocket costs for diagnostic imaging for people with health insurance. While screening mammography is normally covered, additional imaging that’s needed when something suspicious or abnormal is spotted on a mammogram can become pricey. For each of my diagnoses (initial breast cancer diagnosis and diagnosis for residual disease), I required additional diagnostic mammography, diagnostic MRI, and diagnostic ultrasound. They were most DEFINITELY medically necessary to determine that the suspicious lesions on my mammography were indeed cancer – and for past follow-up diagnostic imaging, to determine that suspicious lesions were benign. This legislation will reduce the financial burden for diagnostic imaging that can be a barrier for early diagnosis.
The second piece of legislation, the Metastatic Breast Cancer Access to Care Act, would reduce wait times for receiving Social Security Disability Benefits and Medicare. Right now, the wait time for Medicare benefits for people living with metastatic breast cancer is 5 months, and the average wait for disability is 24 months. The five-year survival rate for stage 4 metastatic breast cancer (MBC) is 22 percent, and the median survival is three years (Reference). As one legislative staffer noted when I spoke with him about the issue and the wait times, “That’s cruel.” It is. People living with MBC need medical care coverage and financial support for themselves and their families. Legislation waiving wait times for ALS and end-stage kidney disease passed, setting a precedent for this important legislation supporting MBC.
Please contact your Senators and Congressional Representative and urge them to co-sponsor and/or support these three key pieces of legislation. Feel free to copy and paste information from this blog post or use it as a script in a phone call.
For a brief, beautiful, shining moment, it was the #1 New Release in Breast Cancer and Oncology on Amazon, and I have the screenshots to commemorate it!
Want a sneak peek? Of course you do! Here’s an excerpt from Chapter 16 that deals with an exciting new development in cancer research and treatment – harnessing the patient’s own immune system to seek out and destroy cancer cells through immune checkpoint inhibitors.
I’ll also take comfort in the fact that we’re getting new weapons in the arsenal for fighting breast cancer. Antitumor immunity is the hottest thing to hit the field of cancer research since the 2001 approval of Gleevec (a game-changer drug used to treat chronic myelogenous leukemia that targets the oncoprotein product of the Philadelphia chromosome that drives the disease) and the 2006 approval of Gardasil (first vaccine targeting the human papilloma virus strains that cause most cervical cancers). Recently Frontiers in Immunology published the history of antitumor immunity efforts leading to the development of immune-checkpoint inhibitors available in the clinic today, the use of engineered T-cells taken from patients and altered to fight their cancer, and oncolytic viruses.2 I’ll go over the basics, including how antitumor immunity works and the challenges we still face in getting tumors to respond.
Before we get into how antitumor immunity works, we need to understand how the immune system works to fight infection. It’s a complex beast, but here are some basics. Your immune system functions to mount a rapid and robust defense when your body encounters a pathogen (e.g., a virus or bacteria that causes disease) in your daily life. The arm of the immune system that does this is called the adaptive immune system (figure 16.1). The other arm is the innate immune system, which includes natural barriers like skin, the tiny hairs and mucous in your nose, and stomach acid. The adaptive immune system is what antitumor immunity treatments harness. It is also altered by tumors to suppress tumor immune responses and exploited to work for the tumor. (More on that in a bit.)
The adaptive immune system works like this: Specialized cells identify a potential threat (e.g., an infection), and they carry information about that threat in the form of bits of protein called antigens to other immune cells. If the threat is credible, those immune cells get activated and fight the threat. First the specialized cells that identify a potential threat patrol your body, looking for something suspicious. Cells like macrophages and dendritic cells, which roam around various organs and tissues, find pathogens (a bacteria, virus, or other microbe that causes disease) or unhealthy cells infected by pathogens, and eat them (the fancy term is phagocytosis). Infected or damaged cells send out protein signals called cytokines as a distress call to attract these patrolling macrophages and dendritic cells. While “digesting” the bacteria or infected cell, macrophages and dendritic cells salvage proteins or pieces of proteins—antigens—that identify the bacteria or virus as “other,” and they present these to immune cells, usually in lymph nodes, which in turn mount an immune response. Macrophages and dendritic cells are known as professional antigen presenting cells (APCs).
When activated by APCs, immune cells called B-cells produce antibodies against the antigen, which can do a lot of things to fight an infection. Some antibodies neutralize the pathogen by binding it and stopping it from entering a cell. Other antibodies tag infected cells as a signal for other immune cells to come and kill them. Others coat pathogens or infected cells in a process called opsonization (meaning “the process of making tasty”), which signals other cells like macrophages to come and eat the coated pathogens or cells. Specialized B-cells called memory B-cells store the information about the antigen so your immune system can recognize the pathogen when it hits you again and mount a faster immune response.
Other immune cells called T-cells, which are particularly relevant to antitumor immunity, become activated by APCs and mount a different kind of immune response. Cytotoxic T-cells seek out and kill infected or damaged cells, and helper T-cells help activate B-cells so they make antibodies, activate cytotoxic T-cells, and activate macrophages to go eat nasty invaders and infected cells. Memory T-cells also store information about past infections to mount a rapid, strong response the next time your body sees it.
That’s a simplified but hopefully digestible explanation of immunity and the major players (there are other immune cells, but APCs, B-cells, and T-cells are the biggies).
Memory is key to protection, and memory is built by exposure to pathogens.
Put a pin in that concept for when we get to anticancer vaccines, and also remember what T-cells do for when we get to engineered CAR T-cells and oncolytic viruses.
Working out how to harness your body’s own immune system to fight cancer isn’t a new idea. It’s been under investigation since the nineteenth century. In fact, in chapter 5 we covered the way trastuzumab (trade name Herceptin), a humanized anti-HER2 antibody, targets HER2-expressing breast cancer cells for death. Herceptin and other monoclonal antibodies mimic the natural activity of antibody- producing B-cells to deliver therapies and tag cancer antigen–expressing cells for immune-mediated destruction. But it was the discovery of checkpoint inhibitors—proteins that put T-cells in a state of exhaustion and inactivity in pathways that are exploited by many cancers— that led to the first molecularly targeted therapies designed to boost antitumor immunity. Doctors James Allison and Tasuku Honjo pioneered this Nobel Prize–winning work.3
What are immune-checkpoint inhibitors, and how do they work? T- cells, particularly cytotoxic T-cells that actively kill their targets, bind to antigens on tumor cells through their T-cell receptors. But tumor cells, being the adaptable beasts that they are, can produce proteins like PD-L1 (programmed death ligand 1), which bind to PD-1 (programmed cell death protein 1), proteins on T-cells. This interaction tells the T- cell to stand down by tricking it into thinking that the tumor cell is “self” and should be protected. Signaling networks like this normally promote self-tolerance so that your immune system doesn’t attack your own healthy cells (figure 16.2). In tumors, it works by telling tumor- infiltrating T-cells, if present, to go into a state of inactivity. Drugs that target PD-L1—like atezolizumab (trade name Tecentriq), durvalumab (trade name Imfinzi), and avelumab (trade name Bavencio)—and drugs that target PD-1—like nivolumab (trade name Opdivo) and pembrozolimuab (trade name Keytruda)—are FDA-approved mono- clonal-antibody therapies that block interactions between PD-1/PD-L1 to unleash an antitumor immune response.4
Other immune-checkpoint molecules exploited by cancers include cytotoxic T lymphocyte antigen 4 (CTLA-4), the target of the first FDA-approved immune-checkpoint inhibitor ipilimumab (trade name Yervoy). Approved in 2011 for advanced melanoma, this drug had remarkable results. In fact, over 20 percent of the patients enrolled in the initial ipilimumab clinical trials (before the 2011 approval) are still alive and show no evidence of disease (NED).
There’s some incredible potential in targeting checkpoint inhibitors.
CTLA-4 is part of a cellular-signaling pathway that normally fine- tunes immune responses. CTLA-4 and a similar receptor, CD28, are expressed on two different T-cell types: (1) CD4+ helper T-cells, which help activate other immune cells to mediate adaptive immune responses, and (2) CD8+ cytotoxic T-cells, those cells that kill infected cells, damaged cells, and, if properly activated, tumor cells. Antigen- presenting cells make a protein called B7, which can bind to either CD28 or CTLA-4 on T-cells, and the effects on T-cell function are very different depending on what B7 binds. If it binds to CD28, B7 activates T-cell responses as a part of a complex of proteins that includes the T-cell receptor. Binding of B7 to CTLA-4 shuts down T- cell functions. CTLA-4 probably serves as protection from self-antigen recognition by inducing immune suppression, since laboratory mouse models engineered to not express CTLA-4 die from autoimmunity. This is the aspect of CTLA-4 function that gets highjacked by tumor cells. Drugs like ipilimumab block the suppressive activity of CTLA-4, which can allow T-cells to attack tumor cells.5
Here’s the kicker: The tumor actually has to have infiltrating T-cells for this to work, and not all tumors do. Tumors with T-cells that can be activated to fight the tumor are called “hot,” whereas tumors without T-cells are “cold.” One of the most aggressively researched topics in tumor immunology right now is how to make a cold tumor hot and thus responsive to antitumor immune therapies.
This is especially important for breast cancer, since most subtypes produce cold tumors. Right now, immune-checkpoint therapies are only approved for advanced triple-negative breast cancers that make the PD-L1 protein. Not all triple-negative breast cancers make PD-L1. Ongoing research is looking to expand the use of immune therapy in inflammatory breast cancer and the HER2+ subtype.6 Hopefully, with more research, we’ll figure out how to make more tumors responsive to immune therapy by making them hot (full of T-cells) and by discover- ing other immune checkpoints that can be targeted.
3. Heidi Ledford, Holly Else, and Matthew Warren, “Cancer Immunologists Scoop Medicine Nobel Prize,” Nature, October 1, 2018, https://www.nature. com/articles/d41586-018-06751-0.
4. See American Cancer Society medical and editorial content team, “Immunotherapy for Breast Cancer,” Treating Breast Cancer, American Cancer Society, Cancer.org, last revised December 3, 2020, https://www.cancer.org/ cancer/breast-cancer/treatment/immunotherapy.html.
6. Devon Carter, “Does Immunotherapy Treat Breast Cancer?” MD Anderson Center (website), University of Texas, March 26, 2021, https://www .mdanderson.org/cancerwise/does-immunotherapy-treat-breast-cancer.h00 -159385101.html.
I can’t believe I have to write this post. I’m shaking my head and weeping for the future of humanity as I write it. Are people really stupid enough to believe that ivermectin – a drug we use in our laboratory mice to treat pinworms (butt worms) – can cure Covid?
Yes (sadly). Yes, they are.
Ivermectin is used to treat butt worms in animals. It can also be used to treat roundworms in people. It works by paralyzing worms, specifically by binding to proteins on motor neurons (nerves that tell muscles to move) and disrupting their activity. It also mucks around with the ability of nematode worms to reproduce.
Fun fact: the naturally occurring analogs of ivermectin, avermectins, were discovered in bacteria from soil samples collected by Dr. Satoshi Ōmura from woods near a golf course in Kawana, on the south east coast of Honshu, Japan. The name “avermectin” reflects the activity of these compounds, making treated organisms “worm free.” Dr. Ōmura and Dr. William Campbell shared the 2015 Nobel Prize in Physiology or Medicine for this discovery. You can read more about that here. Ivermectin in pill form can be used in humans to treat parasitic worms, and topical (on the skin) formulations are also used to treat head lice and rosacea.
It does actually have other, non-butt worm related activities that include treatment of severe muscle spasticity in patients with spinal cord injuries and shows activity against leukemia in laboratory animal models. It may also target molecular pathways relevant to treatment of other cancers, including lung and colon cancer and glioma based on laboratory animal studies, and could block inflammatory T-cell activity in atopic dermatitis, relieving irritation. A recent review covers the research on these applications.
Okay, given these other potential applications, I guess I can kinda sorta see why some folks without a science background might be buying into the idea of using Ivermectin to treat Covid, but(t) still…
This apparently became trendy because of ongoing clinical trials designed to test the efficacy of Ivermectin for Covid-19 treatment and prevention, alone and in combination with other drugs.
Why? Because laboratory studies (in petri dishes in a lab, NOT in people) have shown that Ivermectin can inhibit viral replication, which means it can stop the virus from making copies of itself, which is how it spreads. In vitro. In vitro means “performed or taking place in a test tube, culture dish, or elsewhere outside a living organism.” Plenty of other previous studies showed that ivermectin blocks replication or interferes with the production and spread of other viruses, including HIV, Dengue virus, West Nile virus, and a few others. In vitro. You can review some of these studies here. In spite of these in vitro studies, there is no evidence that ivermectin has any anti-viral effect on the SARS-CoV-2 virus that causes Covid-19. For a link to clinical trial data, click here.
And misuse of ivermectin can be dangerous. According to theFDA,“Even the levels of ivermectin for approved human uses can interact with other medications, like blood-thinners. You can also overdose on ivermectin, which can cause nausea, vomiting, diarrhea, hypotension (low blood pressure), allergic reactions (itching and hives), dizziness, ataxia (problems with balance), seizures, coma and even death.”
The best way to limit the spread of SARS-CoV-2 is to get the vaccine. Period.
And Now for the PSA I never thought I’d have to make…
About the whole so-called “urine therapy” thing – something I never in a million years imagined I would blog about. It isn’t a thing. Apparently, some anti-vaxx conspiracy theory wingnut named Christopher Key has been encouraging his followers to drink their own urine to ward off the SARS-CoV-2 virus instead of getting vaccinated.
For the sake of being thorough and due diligence, I performed a PubMedsearch for “urine therapy covid” on January 16. The search produced 188 results, most dealing with the effects COVID-19 on kidney function, studies related to the potential spread of the virus through urine (risk reported to be negligible), urine-based COVID-19 testing and analysis of cytokines and other diagnostic markers, and testing for SARS-CoV-2 in waste water.
The funniest result was a paper with the title, “Influence of perceived threat of Covid-19 and HEXACO personality traits on toilet paper stockpiling” published inPLoS One.
This one was more sad than funny, but apparently some folks in India are using cow dung to treat COVID-19. People…rubbing animal shit and urine all over your body isn’t effective at treating ANYTHING and is likely to expose you to a whole lot of nasty zoonotic (spread by animals) diseases. Plus you’ll stink. Just…don’t.
You know what I didn’t find in my literature search? I didn’t find a single peer-reviewed study endorsing the use of drinking your own piss as a treatment for COVID-19. Zero, zip, zilch, nada – no evidence to back up this ridiculous claim.
Not that the crazies need silly things like evidence. This actually fits quite nicely with the all-natural woo woo trends. Can you picture it? All natural, locally sourced, sustainably harvested on tap pee pee for your health needs! You’ve heard of eating placenta (don’t do that, either), but why stop there? Drink your pee! When it’s fresh, it looks like a beer.
Sure doesn’t taste like beer. Stick to drinking nice, cold brewskies, and get your vaccine. Please.
I hope everyone is off to a great start – avoiding Covid, staying healthy, and finding happiness and joy wherever you can!
I’m so excited to share news about my new job with the Susan G. Komen Foundation! It may come as a bit of a surprise to those who’ve been following my blog and slices of science and life as a scientist. Why leave research? Well, I actually haven’t left research. I’m just doing a different kind of research. More on that later, but first, why the change? As with any big life decision, there were a LOT of contributing factors. Some of the most important include:
Having an Immediate Impact on Patients and Survivors
I love research, value my time in the laboratory, and appreciate every project I had the opportunity to lead or contribute to in some way. I commend and support my colleagues, especially those who will continue my projects in the lab and build on them to make great strides. Since becoming a survivor, however, something was missing for me. I hope something I’ve done in the lab makes it to the clinic someday, but there’s no guarantee. As a survivor, it’s really important to me to make a difference now. At Komen, I’ll have that opportunity. And I’ll also have the opportunity to support Komen Scholars and grantees conducting research! Since I’ll be coding funded grants (click here for more on Common Scientific Outline [CSO] codes) to capture data, which involves reading applications, I’ll also be able to keep up with the latest advances in the field – advances that I can share with my followers and readers here!
100% Remote Work
This is so great in the age of Covid! I want to protect my health and the health of my loved ones, so being able to work from home minimizes my risk of exposure to the SARS-CoV-2 virus and all its variants. Since I no longer have a commute, I’m saving on gas (and cutting my carbon footprint), can hit the ground running by simply turning on my computer and starting my work day, and I can be more efficient and focused. My furry office mates are great company, and I can eat healthier from home and carve out more time for exercise. No excuses!
Also, with 100% remote work, the job can move with me! My husband and bought land in North Carolina for our dream home last year. We haven’t been able to break ground yet due to ongoing supply chain issues and high prices (Thanks, Covid), but it will happen soon. I didn’t want to be moving while looking for a new job at the same time. Don’t have to worry about that now!
Academic Research is very rewarding and has a lot of pros: flexibility, freedom to pursue a myriad of research directions (so long as you can get funding), and being the first to make a new discovery or push the field forward, to name a few. But there are also challenges. The struggle to acquire funding and increasing competition as funding is limited creates a great deal of stress, not to mention long, long hours generating new preliminary data and preparing new grant applications. Before I left, I submitted three grant applications in the space of two months, and it took a toll on me physically and mentally. It also took me away from the things I love about research, like actually doing experiments, mentoring, networking and collaborating, and it took away so much personal time and time with my family. In academia, you’re never really “off.” You’re constantly bringing home papers to read, answering emails after hours, performing literature searches and working on manuscripts before and after dinner and family time, and often working into the wee hours of the morning. At this point in my life and career, I wanted and needed a better work/life balance – as a human being, as a parent, as a caregiver for aging parents – I needed to stop burning my candle at both ends. Komen is all about work/life balance.
Career Growth and Learning New Skills
As a Research Evaluation Manager, I’ll be tracking the impact of Komen funded research in many areas, including products like biomarkers and new drugs, clinical trials, new interventions, and career progression and trajectories for Komen-funded investigators using data collected by amazing colleagues since the early 1980s. The data are so rich and informative, a veritable history of progress in breast cancer research and milestones in treatments. I’m so excited to dig in! I’ll also be involved in adding to the data by coding newly funded grants, as well as evaluating the impact of research and programs sponsored by Komen. There are a wealth of opportunities, and I’m excited to be a part of it!
I’m also stoked about opportunities in communication and outreach! As a writer and communicator with a mission to bring accessible science to the public, this is my jam! I’m hoping to use the skills I honed from writing Talking To My Tatas to be a vocal and effective ambassador for science and liaison between researchers and stakeholders.
A Mission and Community I Believe In
The mission of Susan G. Komen is to save lives by meeting the most critical needs in our communities and investing in breakthrough research to prevent and cure breast cancer. Everyone working at Komen is 100% committed to this mission, which is patient and survivor focused. It’s not just lip service – many of the colleagues I’ve met in my first week are breast cancer survivors or have been directly impacted by breast cancer through friends, family, and loved ones diagnosed with breast cancer. I feel comfortable sharing my story and feel a deep sense of connection and common purpose when I hear the stories of my colleagues. It makes the work so meaningful. I believe in it, and I’m committed to giving it my all to be a part of the solution to the huge problem that is breast cancer.
Greetings, beautiful people! These past two years have been tough, haven’t they? Pandemic fears, economic woes, and uncertainty about the future have caused everything from low level anxiety to outright terror for so many people. I’ve experienced anxiety during each breast procedure I’ve endured over the past two years, from unilateral mastectomy of my left breast followed by physical therapy, expander fills, autologous DUG flap reconstruction surgery, and three revisions to match size and shape that included fat grafts on the left and and mastopexy plus scar revision on the right.
Of course I was anxious about anesthesia, outcome, what I was putting my body through – again – and when it might end. But I was also terrified of exposure to the Covid virus.
Then, I imagined how terrified patients undergoing chemo and radiation must feel, knowing they are at an even higher risk due to a compromised immune system. If you are one of those patients, check out these resources from the American Cancer Society.
That’s left me feeling pretty powerless, and I don’t like that feeling. What can I do? How can I help?
In addition to working in the lab, sharing my knowledge and experience, and giving to my organization, I’ve found giving to organizations dedicated to helping patients facing cancer empowering. These organizations do fantastic work. They not only fund research for tomorrow’s new treatments, they also fund initiative to help patients today. Right now.
For #GivingTuesday2021, I’ve chosen Susan G. Komen for the Cure. Like ACS, they support research, outreach and advocacy, and provide patient resources and support. And they are fully breast cancer focused, providing information and also financial assistance to patients in need – that’s SUPER important in these difficult times. SGK has supported my survivor sisters and their families, my colleagues in research, and they will continue to do so thanks to the generosity of donors.
You don’t have to break the bank to support them, either. Small donations really add up, especially with matching initiatives from partnering sponsors. In fact, donations made to SGK through December 1 have DOUBLE the impact thanks to matching. So this year, consider supporting SGK for Giving Tuesday.
Here are some other great breast cancer/cancer focused organizations you can support, many of which are highlighted in my book and many of which focus on healthcare equity and equality.
OrganizationsYou Can Support
METAvivor is an organization that supports patients with metastatic breast cancer and funds research that specifically seeks to improve outcomes for patients with metastatic disease, https://www.metavivor.org/
Sisters Network, Inc., brings awareness of the impact breast cancer has on the African American community and provides a space for African American breast cancer patients to meet, bond, and receive support while receiving cancer treatment, http://www.sistersnetworkinc.org/.
The African American Breast Cancer Alliance focuses on promoting awareness, early detection, and prevention while providing emotional and social support with culturally specific information and programs for women of color, https://www.aahafortwayne.org/.
Sisters by Choice seeks to eliminate access barriers to screenings and quality care for breast cancer, including a mobile clinic to bring care to uninsured and underserved communities in Georgia, https://www.sistersbychoice.org/.
Black Women’s Health Imperative focuses on improving overall health and wellness of African American women and girls, provides outreach and curates black women’s health data through its #WeRefuse initiative for breast cancer, https://bwhi.org/.
Latinas Contra Cancer is dedicated to creating an inclusive healthcare system for cancer care in the underserved Hispanic/Latina population, http://latinascontracancer.org/.
The Latino Cancer Institute is devoted to promoting education, services, research, and policies that impact Hispanics/Latinos in the United States when it comes to cancer, https://latinocancerinstitute.org/.
The American Indian Cancer Foundation seeks to eliminate cancer burdens of Indigenous people by improving access to prevention, early detection, treatment, and support for survivors, https://www.americanindiancancer.org/.
Asian American Cancer Support Network is dedicated to providing education, support and a diverse network of resources for Asian Americans affected by cancer, http://aacsn.org/.
Maina Foundation is dedicated to raising awareness and support for breast cancer early detection among South Asian Indian women, https://mainafoundation.org/.
The American Association of People with Disabilities is dedicated to increasing political and economic power for people with disabilities, supports access to quality comprehensive and affordable healthcare for people with disabilities as part of their mission, https://www.aapd.com/.
American Association on Intellectual and Developmental Disabilities works to protect the universal human rights of people with intellectual and developmental disabilities, supports access to quality healthcare, https://www.aaidd.org/.
National LGBT Cancer Network, an organization that provides education, support, and advocacy for LGBT cancer patients and survivors, and also maintains a directory of LGBT-friendly cancer treatment facilities, https://cancer-network.org/.
National LGBT Cancer Project, an organization providing support and advocacy for LGBT cancer survivors and supporting equal and appropriate access to cancer care for the LGBT community, https://www.lgbtcancer.org/.
Got any other organizations to add to my list? Send them my way! Please!
Sometimes, if you’re lucky, something comes into your life just when you need it the most. That was my introduction to The Bloggess (aka Jenny Lawson aka Amazing/Funny/Fabulous human being). I LOVED her first book, Let’s Pretend This Never Happened (A Mostly True Memoir), gifted to me by my BFF. If you haven’t read it, treat yourself. Her other books are just as poignant, engaging, and hilarious. They’re like Pokemon – gotta catch them all! Or maybe potato chips – betcha can’t read just one. Something like that.
Better yet, grab the Audiobook! Jenny narrates it, and the humor and heartache and hope just flows from her voice directly to your brain cells, releasing serotonin and making you feel better no matter what you’re going through. Which brings me back to my first point – the something-that-comes-into-your-life-just-when-you-need-it-the-most point:
The day I endured two breast biopsies was a bad day. It would have been worse without Jenny, who allowed me to escape into her world and kept me company while I was waiting to go on the slab. And guess what?
SHE FOLLOWED ME BACK ON TWITTER!!!!
This was the highlight of my year, people! It also kept me going and inspired me while writing Talking to My Tatas. Jenny’s story touched and inspired millions, and she’s saved lives, y’all! I wanted to do the same. Whenever I got frustrated, stuck, or wanted to just give up on the writing, querying, and rejections, I remembered Jenny.
Fast-forward to the present, and guess what? Jenny Lawson endorsed my book!
“I don’t know much about cancer, but I know good writing and humor, and Dana Brantley-Sieders has those in spades.” — Jenny Lawson, #1 New York Times-bestselling author of “Let’s Pretend This Never Happened”
I’m delighted, grateful, and I’m totally going to stalk visit her at The Nowhere Bookshop someday soon. Thanks, Babe!
It’s been a while. This is my first post for Breast Cancer Awareness Month 2021, but I promise I’ve been busy in the laboratory. In the past two months, I’ve submitted grant applications to Breast Cancer Alliance, METAvivor, and Department of Defense CDMRP Breast Cancer Research Program. The first two are foundations that fund novel research projects, supporting scientists like me so we can take a chance on new projects that are higher risk/high reward and generate preliminary data for larger funding proposals. DOD supports larger research projects at both early (Breakthrough Level 1) and later (Breakthrough Level 2) stages. Fingers and toes crossed for grant funding! If you’re looking for organizations to support, I highly recommend Breast Cancer Alliance and METAvivor.
For this post, I’d like to highlight some survivor communities that have helped me and continue to help me, and to encourage patients and survivors to reach out for support. Cancer made me feel powerless. Sure, I was taking care of myself and following instructions from my surgeons, oncologist, and other providers, but they were doing things to me and for me – cutting out the cancer, managing my followup therapies, monitoring me to make sure the cancer wasn’t back, but I felt like I wasn’t (or couldn’t) do anything. That’s part of the reason I wrote Talking To My Tatas and why I started this blog. I needed to DO something.
I also needed to know I wasn’t alone. Enter other breast cancer patients and survivors. These people are some of the most generous human beings, providing support, practical advice, sharing their stories, and giving lots and lots of love to people who join this club we never wanted to be a part of but is filled with survivors in every sense of the word.
Where can you find support? Plenty of places! The Internet can be a terrible and wonderful place, and in the case of support for cancer patients and survivors, it can be a lifeline. Here are some survivor communities who’ve helped see me through on Facebook:
This is a large FB group dedicated to shared experiences and full of practical advice! I went to them when I was preparing for my mastectomy and I got a TON of tips for what to expect, what to stock up on (soft cotton camis and cardigans with pockets for surgical drains, pillows, etc.). Need advice from folks who’ve been there? Need to vent? Looking for hope? A safe place to express yourself? This is a great one!
Want to know about the latest research? Looking to connect with survivors and get involved in advocacy, or do you need information on resources from financial to physical and mental health? This group is a great place to start.
No matter your background, culture, or identity, you don’t have to go it alone when it comes to breast cancer. I encourage you to find your support network and lean on them. And, when you’re ready, be a part of that community and give your support to someone in need.
I am so fortunate to have the support I do for this project, from fellow survivor sisters to a leading expert in the fight against cancer. Shout out to the incomparable Dr. Alice Randall, the amazing Cynthia D’Alba (a.k.a. Dr. Cynthia D. Morgan, EdD), and Dr. Lynn Matrisian for taking the time to read the uncorrected proof of Talking to My Tatas and providing such outstanding endorsements!
“Reading Talking to My Tatas is a little like discovering you have a wise and funny friend who is an expert on breasts and breast cancer and is willing to talk through your worries anytime of the night or day. This is the book I wish existed when I was diagnosed with breast cancer. Don’t send a casserole. Send Talking to My Tatas.”
—Alice Randall, professor and writer-in-residence, Department of African-American and Diaspora Studies, Vanderbilt University
“Talking to My TaTas contains the factual information that all newly diagnosed breast cancer patients need, but presented in an easily understood, and sometimes humorous, style that will appeal to non-medical as well as medical breast cancer patients. Talking to My Tatas is a deep dive into the personal world and experiences of a breast cancer researcher and survivor who isn’t afraid to pull back the curtain on breast cancer reality. The author does a credible job debunking myths, falsehoods, and junk cancer therapies, leaving the authenticity only a person steeped in cancer research and cancer treatment can. As a two-time breast cancer survivor, I can recommend this book unreservedly.”
—Cynthia D’Alba, New York Times and USA Today bestselling author, breast cancer survivor, 2016 and 2021
“Informative, witty, and engaging, Dr. Brantley-Sieders effectively combines her scientific training and her personal experience to tell it like it is.”
—Lynn M. Matrisian, PhD, MBA, Chief Science Officer, Pancreatic Cancer Action Network
These women represent my two worlds: survivor/advocate and scientist. Both of these worlds have shaped me and made me who I am, as have these incredible human beings who’ve their support to my work. I am forever grateful!